6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3-4]pyrrolo[1-3-d]pyridazinone and Inflammation

6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3-4]pyrrolo[1-3-d]pyridazinone has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3-4]pyrrolo[1-3-d]pyridazinone and Inflammation

Article	Year
SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE. Viruses, 2022, 05-06, Volume: 14, Issue:5 Clinical studies indicate that patients infected with SARS-CoV-2 develop hyperinflammation, which correlates with increased mortality. The SARS-CoV-2/COVID-19-dependent inflammation is thought to occur via increased cytokine production and hyperactivity of RAGE in several cell types, a phenomenon observed for other disorders and diseases. Metabolic reprogramming has been shown to contribute to inflammation and is considered a hallmark of cancer, neurodegenerative diseases, and viral infections. Malfunctioning glycolysis, which normally aims to convert glucose into pyruvate, leads to the accumulation of advanced glycation end products (AGEs). Being aberrantly generated, AGEs then bind to their receptor, RAGE, and activate several pro-inflammatory genes, such as IL-1b and IL-6, thus, increasing hypoxia and inducing senescence. Using the lung epithelial cell (BEAS-2B) line, we demonstrated that SARS-CoV-2 proteins reprogram the cellular metabolism and increase pyruvate kinase muscle isoform 2 (PKM2). This deregulation promotes the accumulation of AGEs and senescence induction. We showed the ability of the PKM2 stabilizer, Tepp-46, to reverse the observed glycolysis changes/alterations and restore this essential metabolic process. Topics: COVID-19; Humans; Inflammation; Pneumonia; Pyridazines; Pyrroles; SARS-CoV-2	2022
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4 Cell metabolism, 2020, 02-04, Volume: 31, Issue:2 Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. Here, we report PKM2 upregulation, phosphorylation, and nuclear accumulation in murine and human CD4 Topics: Animals; Autoimmunity; Carrier Proteins; Cells, Cultured; Enzyme Activators; Female; Humans; Inflammation; Membrane Proteins; Mice; Mice, Inbred C57BL; Pyridazines; Pyrroles; Th1 Cells; Thyroid Hormone-Binding Proteins; Thyroid Hormones	2020

Article

Year

SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE.

Viruses, 2022, 05-06, Volume: 14, Issue:5

Clinical studies indicate that patients infected with SARS-CoV-2 develop hyperinflammation, which correlates with increased mortality. The SARS-CoV-2/COVID-19-dependent inflammation is thought to occur via increased cytokine production and hyperactivity of RAGE in several cell types, a phenomenon observed for other disorders and diseases. Metabolic reprogramming has been shown to contribute to inflammation and is considered a hallmark of cancer, neurodegenerative diseases, and viral infections. Malfunctioning glycolysis, which normally aims to convert glucose into pyruvate, leads to the accumulation of advanced glycation end products (AGEs). Being aberrantly generated, AGEs then bind to their receptor, RAGE, and activate several pro-inflammatory genes, such as IL-1b and IL-6, thus, increasing hypoxia and inducing senescence. Using the lung epithelial cell (BEAS-2B) line, we demonstrated that SARS-CoV-2 proteins reprogram the cellular metabolism and increase pyruvate kinase muscle isoform 2 (PKM2). This deregulation promotes the accumulation of AGEs and senescence induction. We showed the ability of the PKM2 stabilizer, Tepp-46, to reverse the observed glycolysis changes/alterations and restore this essential metabolic process.

Topics: COVID-19; Humans; Inflammation; Pneumonia; Pyridazines; Pyrroles; SARS-CoV-2

2022

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4

Cell metabolism, 2020, 02-04, Volume: 31, Issue:2

Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. Here, we report PKM2 upregulation, phosphorylation, and nuclear accumulation in murine and human CD4

Topics: Animals; Autoimmunity; Carrier Proteins; Cells, Cultured; Enzyme Activators; Female; Humans; Inflammation; Membrane Proteins; Mice; Mice, Inbred C57BL; Pyridazines; Pyrroles; Th1 Cells; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2020